Drupal pages and nodes can be themed using Contemplate module. It is an option for basic users. But, if you are a programmer, you should use the template system. For example, you can add new templates in your theme folder like page-front.tpl.php to style to homepage, or node-blog.tpl.php to style blog node typs.
In Drupal 7 it will be page--front.tpl.php (double -), and node--blog.tpl.php
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